Abrogation of the interferon response promotes more efficient human cytomegalovirus replication.
نویسندگان
چکیده
The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling HCMV replication and provide useful tools to investigate the IFN response to HCMV.
منابع مشابه
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عنوان ژورنال:
- Journal of virology
دوره 89 2 شماره
صفحات -
تاریخ انتشار 2015